Synthesis and Antitubercular activity of novel lupeol derivatives

Recently, one third of the world’s population is infected with Mycobacterium tuberculosis and 8 million new and relapse cases of tuberculosis are reported every year. The emergence of new cases, the increased incidence of multidrug resistant strains of M. tuberculosis, and the adverse effects of first and second-line antituberculosis drugs have led to renewed research interest in natural products in the hope of discovering new antitubercular leads. Now a days, thousand of Natural and semisynthetic derivatives ,possessing novel, compounds have been reported to positive activity towards M.tuberculosis. In this paper we isolate lupeol first then formation of their pyrazoline derivative .Few derivative of lupeol showed more potent and significant antitubercular activity. In our studies, it was found that the pyrazoline derivatives of lupeol possess better antitubercular potential when compared to lupeol. In this cases natural products such as lupeol with low bioactivity (MICs of 64 μg/ mL), and also those semisynthetic derivatives with remarkable antitubercular activity (MICs of 8.5μg/mL). It is thus concluded that lupeol skeleton deserves further investigation for the development of more potent and non-toxic new antitubercular agents for therapeutic applications.